Hair Loss Prevention: PRP, PRF, Polynucleotides and Microneedling
Hair loss is much easier to treat early than once significant follicle loss has occurred. At The Sana Clinic, hair restoration begins with a doctor-led consultation, detailed medical history and scalp analysis, so treatment is tailored to the cause, stage and pattern of hair loss.
Why does early hair loss treatment matter?
Hair thinning is often progressive. For many patients, the aim is not only to regrow hair, but to slow shedding, strengthen existing follicles and prevent hair loss from reaching the stage where a hair transplant becomes necessary.
Compared with hair transplant surgery, regenerative hair treatments usually involve less downtime, lower risk and a more accessible treatment journey. Surgery may still be appropriate for advanced hair loss, but early intervention is often the more elegant and preventative approach.
What treatments are used for hair loss prevention?
At The Sana Clinic, hair loss prevention may include PRP, PRF, polynucleotides and microneedling.
PRP and PRF use concentrated components from your own blood, rich in growth factors, which are placed back into the scalp. Polynucleotides support tissue repair and scalp health, while microneedling creates controlled stimulation that can enhance the regenerative response.
Treatment outcomes can also be supported with medical-grade shampoos and conditioners, alongside prescriptions such as minoxidil or finasteride where clinically appropriate.
What results can patients expect?
Results vary depending on the diagnosis, stage of hair loss, treatment plan and consistency.
Published studies are encouraging. One study reported an average hair-count increase of 17.88% with PRP alone and 24.53% when PRP was combined with microneedling. Another study found that 66% of patients achieved “very good” results after four PRP and microneedling sessions.
Polynucleotide research for hair loss is newer, but one 2025 study reported patient-assessed improvement in 82.1% of androgenetic alopecia cases after four treatments.
These figures are not guarantees, but they do support the role of regenerative medicine in carefully selected patients.
Is this suitable for postpartum hair loss?
It can be, depending on the cause. Postpartum hair loss is often linked to telogen effluvium, where shedding increases after a trigger such as childbirth. It can be temporary, but it can also reveal underlying issues such as iron deficiency, thyroid imbalance or female pattern hair loss.
This is why a doctor-led assessment is important before starting treatment.
How is progress measured?
Dr Sana uses a trichoscope, a specialist medical device that magnifies the scalp and hair follicles. This allows reports to be created using objective data, including hair density, follicle quality and scalp changes over time.
Progress is therefore assessed with medical evidence, not just photographs.
Why is treatment more comfortable at The Sana Clinic?
Dr Sana has developed a proprietary PRP and PRF protocol focused on obtaining high-quality preparation and delivering treatment precisely.
The clinic has also invested in a high-end medical mesotherapy gun, allowing PRP and PRF injections to be performed quickly, evenly and with significantly less discomfort than traditional manual scalp injections.
How do I know if I am suitable?
The first step is a consultation. Dr Sana will assess your scalp, medical history, medications, lifestyle and treatment goals before creating a personalised plan.
Book a consultation at The Sana Clinic in Marylebone or Canary Wharf to discuss a bespoke hair loss prevention plan.
References
Iftikhar N, Nasir N, Khan W, et al. Comparison of Efficacy of Platelet-Rich Plasma (PRP) With PRP Microneedling in Androgenetic Alopecia. Cureus. 2022.
Yepuri V, Venkataram M. Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia: Study of Efficacy of the Treatment and the Number of Sessions Required. Journal of Cutaneous and Aesthetic Surgery. 2021.
Anitua E, Tierno R, Alkhraisat MH. Platelet-Rich Plasma in the Management of Alopecia: A Systematic Review and Meta-Analysis of Clinical Evidence. Dermatology and Therapy. 2025.
Thanasarnaksorn W, Limsuchaiwat N, Sirithanabadeekul P, et al. Polynucleotides as a Novel Therapeutic Approach in Androgenetic Alopecia: An Analysis of Effectiveness and Safety. Archives of Dermatological Research. 2025.
English RS Jr, Ruiz S, DoAmaral P. Microneedling and Its Use in Hair Loss Disorders: A Systematic Review. Dermatology and Therapy. 2022.
British Association of Dermatologists. Telogen Effluvium Patient Information Leaflet. Updated October 2025.
NHS. Hair Transplant. NHS Tests and Treatments. Last reviewed September 2023.
